IL-4 receptors on human medulloblastoma tumours serve as a sensitive target for a circular permuted IL-4-Pseudomonas exotoxin fusion protein

Cytotoxins directed to interleukin-4 receptors have shown to mediate relatively selective cytotoxicity against a variety of human cancer cells in vitro and in vivo. In an ongoing Phase I clinical trial, a recombinant protein comprised of circularly permuted IL-4 fused to a mutated form of Pseudomona...

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Detalles Bibliográficos
Autores principales: Joshi, B H, Leland, P, Silber, J, Kreitman, R J, Pastan, I, Berger, M, Puri, R K
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375174/
https://www.ncbi.nlm.nih.gov/pubmed/11870521
http://dx.doi.org/10.1038/sj.bjc.6600034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375174/
https://www.ncbi.nlm.nih.gov/pubmed/11870521
http://dx.doi.org/10.1038/sj.bjc.6600034

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