Prerequisites for effective adenovirus mediated gene therapy of colorectal liver metastases in the rat using an intracellular neutralizing antibody fragment to p21-Ras

Ras mutations are present in 40–50% of colorectal cancers. Inactivating this oncogene may therefore reduce proliferation capacity. In order to target ras we studied the transduction efficacy and anti tumour activity of an adenoviral vector expressing an intracellular, neutralizing single chain antib...

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Detalles Bibliográficos
Autores principales: van Etten, B, ten Hagen, T L M, de Vries, M R, Ambagtsheer, G, Huet, T, Eggermont, A M M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375217/
https://www.ncbi.nlm.nih.gov/pubmed/11875712
http://dx.doi.org/10.1038/sj.bjc.6600089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375217/
https://www.ncbi.nlm.nih.gov/pubmed/11875712
http://dx.doi.org/10.1038/sj.bjc.6600089

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