Abnormal FHIT expression profiles in cervical intraepithelial neoplastic (CIN) lesions

Abnormal fragile histidine triad transcripts were found in 20–30% of CIN2/3 lesions and 11% of normal cervical biopsies by RT–PCR. Bi-allelic loss of the fragile histidine triad gene and the loss of fragile histidine triad protein expression detectable by immunochemical staining with a polyclonal fr...

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Autores principales: Terry, G, Ho, L, Londesborough, P, Cuzick, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375220/
https://www.ncbi.nlm.nih.gov/pubmed/11875703
http://dx.doi.org/10.1038/sj.bjc.6600077
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author Terry, G
Ho, L
Londesborough, P
Cuzick, J
author_facet Terry, G
Ho, L
Londesborough, P
Cuzick, J
author_sort Terry, G
collection PubMed
description Abnormal fragile histidine triad transcripts were found in 20–30% of CIN2/3 lesions and 11% of normal cervical biopsies by RT–PCR. Bi-allelic loss of the fragile histidine triad gene and the loss of fragile histidine triad protein expression detectable by immunochemical staining with a polyclonal fragile histidine triad specific antibody was rare. The genomic changes showed no association with the presence of human papillomavirus types which carry high risk for cervical cancer (high risk human papillomavirus) as assessed by a type-specific multiplex PCR. The presence of abnormal fragile histidine triad transcripts in a subset of CIN2/3 lesions with no high risk human papillomavirus suggests that this could be an independent risk factor associated with an alternative carcinogenic pathway. British Journal of Cancer (2002) 86, 376–381. DOI: 10.1038/sj/bjc/6600077 www.bjcancer.com © 2002 The Cancer Research Campaign
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spelling pubmed-23752202009-09-10 Abnormal FHIT expression profiles in cervical intraepithelial neoplastic (CIN) lesions Terry, G Ho, L Londesborough, P Cuzick, J Br J Cancer Molecular and Cellular Pathology Abnormal fragile histidine triad transcripts were found in 20–30% of CIN2/3 lesions and 11% of normal cervical biopsies by RT–PCR. Bi-allelic loss of the fragile histidine triad gene and the loss of fragile histidine triad protein expression detectable by immunochemical staining with a polyclonal fragile histidine triad specific antibody was rare. The genomic changes showed no association with the presence of human papillomavirus types which carry high risk for cervical cancer (high risk human papillomavirus) as assessed by a type-specific multiplex PCR. The presence of abnormal fragile histidine triad transcripts in a subset of CIN2/3 lesions with no high risk human papillomavirus suggests that this could be an independent risk factor associated with an alternative carcinogenic pathway. British Journal of Cancer (2002) 86, 376–381. DOI: 10.1038/sj/bjc/6600077 www.bjcancer.com © 2002 The Cancer Research Campaign Nature Publishing Group 2002-02-01 /pmc/articles/PMC2375220/ /pubmed/11875703 http://dx.doi.org/10.1038/sj.bjc.6600077 Text en Copyright © 2002 The Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular and Cellular Pathology
Terry, G
Ho, L
Londesborough, P
Cuzick, J
Abnormal FHIT expression profiles in cervical intraepithelial neoplastic (CIN) lesions
title Abnormal FHIT expression profiles in cervical intraepithelial neoplastic (CIN) lesions
title_full Abnormal FHIT expression profiles in cervical intraepithelial neoplastic (CIN) lesions
title_fullStr Abnormal FHIT expression profiles in cervical intraepithelial neoplastic (CIN) lesions
title_full_unstemmed Abnormal FHIT expression profiles in cervical intraepithelial neoplastic (CIN) lesions
title_short Abnormal FHIT expression profiles in cervical intraepithelial neoplastic (CIN) lesions
title_sort abnormal fhit expression profiles in cervical intraepithelial neoplastic (cin) lesions
topic Molecular and Cellular Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375220/
https://www.ncbi.nlm.nih.gov/pubmed/11875703
http://dx.doi.org/10.1038/sj.bjc.6600077
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AT londesboroughp abnormalfhitexpressionprofilesincervicalintraepithelialneoplasticcinlesions
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