A fully human anti-Ep-CAM scFv-beta-glucuronidase fusion protein for selective chemotherapy with a glucuronide prodrug

Monoclonal antibodies against tumour-associated antigens could be useful to deliver enzymes selectively to the site of a tumour for activation of a non-toxic prodrug. A completely human fusion protein may be advantageous for repeated administration, as host immune responses may be avoided. We have c...

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Detalles Bibliográficos
Autores principales: de Graaf, M, Boven, E, Oosterhoff, D, van der Meulen-Muileman, I H, Huls, G A, Gerritsen, W R, Haisma, H J, Pinedo, H M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375299/
https://www.ncbi.nlm.nih.gov/pubmed/11875747
http://dx.doi.org/10.1038/sj.bjc.6600143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375299/
https://www.ncbi.nlm.nih.gov/pubmed/11875747
http://dx.doi.org/10.1038/sj.bjc.6600143

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