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Inhibition of the alpha-ν integrins with a cyclic RGD peptide impairs angiogenesis, growth and metastasis of solid tumours in vivo
Anti-angiogenetic cancer therapy is a potential new form for treatment of solid tumours. The α(v)-integrins (α(v)β(3), α(v)β(5)) mediate the contact of activated endothelial cells to proteins of the extracellular matrix during tumour angiogenesis as a prerequisite for survival of endothelial cells....
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2002
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375318/ https://www.ncbi.nlm.nih.gov/pubmed/11875744 http://dx.doi.org/10.1038/sj.bjc.6600141 |