In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles

Novel 2-(4-aminophenyl)benzothiazoles possess highly selective, potent antitumour properties in vitro and in vivo. They induce and are biotransformed by cytochrome P450 (CYP) 1A1 to putative active as well as inactive metabolites. Metabolic inactivation of the molecule has been thwarted by isosteric...

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Detalles Bibliográficos
Autores principales: Bradshaw, T D, Chua, M-S, Browne, H L, Trapani, V, Sausville, E A, Stevens, M F G
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375326/
https://www.ncbi.nlm.nih.gov/pubmed/11953897
http://dx.doi.org/10.1038/sj.bjc.6600225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375326/
https://www.ncbi.nlm.nih.gov/pubmed/11953897
http://dx.doi.org/10.1038/sj.bjc.6600225

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