Cargando…

Cirrhotic livers reveal genetic changes in the MDM2-P14ARF system of cell cycle regulators

The genesis of hepatocellular carcinoma is promoted by changes in the regulatory MDM2-P14ARF system. The incidence of such changes has to date not been analysed in non-tumourous livers showing regenerative proliferation. In the present study, 24 cirrhotic livers of alcohol-, autoimmue disorder- or H...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schlott, T, Scharf, J G, Gorzel, C, Middel, P, Spring, H
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2002
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375354/ https://www.ncbi.nlm.nih.gov/pubmed/11953887 http://dx.doi.org/10.1038/sj.bjc.6600238

Ejemplares similares

Germline mutations of the INK4a-ARF gene in patients with suspected genetic predisposition to melanoma
por: Soufir, N, et al.
Publicado: (2004)

Genetic Variation in MDM2 and p14 (ARF) and Susceptibility to Salivary Gland Carcinoma
por: Jin, Lei, et al.
Publicado: (2012)

MDM2-Mediated Degradation of p14ARF: A Novel Mechanism to Control ARF Levels in Cancer Cells
por: Vivo, Maria, et al.
Publicado: (2015)

Search for germline alterations in CDKN2A/ARF and CDK4 of 42 Jewish melanoma families with or without neural system tumours
por: Marian, C, et al.
Publicado: (2005)

Pinning Control for the p53-Mdm2 Network Dynamics Regulated by p14ARF
por: Suarez, Oscar J., et al.
Publicado: (2020)

The association between the T309G polymorphism of the MDM2 gene and sensitivity to anticancer drug is dependent on the p53 mutational status in cellular models
por: Faur, N, et al.
Publicado: (2009)

The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
por: Sinilnikova, O M, et al.
Publicado: (2009)

Genetic diversity of the Nubian ibex in Oman as revealed by mitochondrial DNA
por: Al-Ghafri, Mataab K., et al.
Publicado: (2021)

High-resolution genome-wide allelotype analysis identifies loss of chromosome 14q as a recurrent genetic alteration in astrocytic tumours
por: Hu, J, et al.
Publicado: (2002)

Frequent downregulation of 14-3-3 σ protein and hypermethylation of 14-3-3 σ gene in salivary gland adenoid cystic carcinoma
por: Uchida, D, et al.
Publicado: (2004)

Overexpression of CCDC69 activates p14(ARF)/MDM2/p53 pathway and confers cisplatin sensitivity
por: Cui, Long, et al.
Publicado: (2019)

Bivalent binding of p14ARF to MDM2 RING and acidic domains inhibits E3 ligase function
por: Kowalczyk, Dominika, et al.
Publicado: (2022)

Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity
por: Pope, Welkin H, et al.
Publicado: (2015)

Simultaneous quantification of mRNA and protein in single cells reveals post-transcriptional effects of genetic variation
por: Brion, Christian, et al.
Publicado: (2020)

Genetic affinity between Ningxia Hui and eastern Asian populations revealed by a set of InDel loci
por: Zhou, Boyan, et al.
Publicado: (2020)

Genetic and epigenetic changes in primary metastatic and nonmetastatic colorectal cancer
por: Miranda, E, et al.
Publicado: (2006)

hCINAP alleviates senescence by regulating MDM2 via p14ARF and the HDAC1/CoREST complex
por: Huang, Xinping, et al.
Publicado: (2023)

Genetic Variants in the p14ARF/MDM2/TP53 Pathway Are Associated with the Prognosis of Esophageal Squamous Cell Carcinoma Patients Treated with Radical Resection
por: Li, Jing, et al.
Publicado: (2016)

Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis
por: Cunningham, J M, et al.
Publicado: (2009)

Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours
por: Carén, H, et al.
Publicado: (2007)

Genetic dissection of morphological variation between cauliflower and a rapid cycling Brassica oleracea line
por: Shuang, Lan Shuan, et al.
Publicado: (2023)

Telomerase activity, apoptosis and cell cycle progression in ataxia telangiectasia lymphocytes expressing TCL1
por: Gabellini, C, et al.
Publicado: (2003)

Differential disruption of cell cycle pathways in small cell and non-small cell lung cancer
por: Coe, B P, et al.
Publicado: (2006)

LRP6 targeting suppresses gastric tumorigenesis via P14(ARF)–Mdm2–P53-dependent cellular senescence
por: Wang, Haibin, et al.
Publicado: (2017)

Genetically engineered insects with sex-selection and genetic incompatibility enable population suppression
por: Upadhyay, Ambuj, et al.
Publicado: (2022)

Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice
por: Smith, Clare M, et al.
Publicado: (2022)

Interaction between polymorphisms in cell-cycle genes and environmental factors in regulating cholinesterase activity in people with exposure to omethoate
por: Duan, Xiaoran, et al.
Publicado: (2018)

ARF: a versatile DNA damage response ally at the crossroads of development and tumorigenesis
por: Kotsinas, Athanassios, et al.
Publicado: (2014)

A discrete choice experiment of preferences for genetic counselling among Jewish women seeking cancer genetics services
por: Peacock, S, et al.
Publicado: (2006)

Correction: NLRP6 targeting suppresses gastric tumorigenesis via P14(ARF)–Mdm2–P53-dependent cellular senescence
por: Wang, Haibin, et al.
Publicado: (2018)

Genome-Wide Identification and Comparative Analysis of ARF Family Genes in Three Apiaceae Species
por: Pei, Qiaoying, et al.
Publicado: (2021)

Genetic and metabolic predictors of chemosensitivity in oligodendroglial neoplasms
por: Walker, C, et al.
Publicado: (2006)

Genetic parameters for body weight in meat quail
por: Barbieri, A., et al.
Publicado: (2015)

Genetic variation in adaptability and pleiotropy in budding yeast
por: Jerison, Elizabeth R, et al.
Publicado: (2017)

Genetic and environmental perturbations lead to regulatory decoherence
por: Lea, Amanda, et al.
Publicado: (2019)

Genetic analysis of Boletus edulis suggests that intra-specific competition may reduce local genetic diversity as a woodland ages
por: Hoffman, J. I., et al.
Publicado: (2020)

Neuroendocrinology of the lung revealed by single-cell RNA sequencing
por: Kuo, Christin S, et al.
Publicado: (2022)

Genetics Adviser: a protocol for a mixed-methods randomised controlled trial evaluating a digital platform for genetics service delivery
por: Shickh, Salma, et al.
Publicado: (2022)

Genetic abnormalities detected in ependymomas by comparative genomic hybridisation
por: Carter, M, et al.
Publicado: (2002)

Molecular diagnosis of primary liver cancer by microsatellite DNA analysis in the serum
por: Chang, Y-C, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_biocce7kj3d194i0o0useuf35u