Cytotoxicity of rhein, the active metabolite of sennoside laxatives, is reduced by multidrug resistance-associated protein 1

Anthranoid laxatives, belonging to the anthraquinones as do anthracyclines, possibly increase colorectal cancer risk. Anthracyclines interfere with topoisomerase II, intercalate DNA and are substrates for P-glycoprotein and multidrug resistance-associated protein 1. P-glycoprotein and multidrug resi...

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Detalles Bibliográficos
Autores principales: van Gorkom, B A P, Timmer-Bosscha, H, de Jong, S, van der Kolk, D M, Kleibeuker, J H, de Vries, E G E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375364/
https://www.ncbi.nlm.nih.gov/pubmed/11986786
http://dx.doi.org/10.1038/sj.bjc.6600255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375364/
https://www.ncbi.nlm.nih.gov/pubmed/11986786
http://dx.doi.org/10.1038/sj.bjc.6600255

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