Cytostatic potential of novel agents that inhibit the regulation of intracellular pH

Cells within the acidic extracellular environment of solid tumours maintain their intracellular pH (pHi) through the activity of membrane-based ion exchange mechanisms including the Na(+)/H(+) antiport and the Na(+)-dependent Cl(−)/HCO(3)(−) exchanger. Inhibition of these regulatory mechanisms has b...

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Detalles Bibliográficos
Autores principales: Wong, P, Kleemann, H-W, Tannock, I F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376112/
https://www.ncbi.nlm.nih.gov/pubmed/12107849
http://dx.doi.org/10.1038/sj.bjc.6600424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376112/
https://www.ncbi.nlm.nih.gov/pubmed/12107849
http://dx.doi.org/10.1038/sj.bjc.6600424

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