Low frequency of somatic mutations in the FH/multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomas

Germline mutations in the fumarate hydratase gene at 1q43 predispose to dominantly inherited skin and uterine leiomyomata and leiomyosarcomas. The enzyme, which is a component of the tricarboxylic acid cycle, acts as a tumour suppressor. To evaluate fumarate hydratase in respective sporadic tumours,...

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Detalles Bibliográficos
Autores principales: Barker, K T, Bevan, S, Wang, R, Lu, Y-J, Flanagan, A M, Bridge, J A, Fisher, C, Finlayson, C J, Shipley, J, Houlston, R S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376129/
https://www.ncbi.nlm.nih.gov/pubmed/12177782
http://dx.doi.org/10.1038/sj.bjc.6600502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376129/
https://www.ncbi.nlm.nih.gov/pubmed/12177782
http://dx.doi.org/10.1038/sj.bjc.6600502

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