CHEK2 variants in susceptibility to breast cancer and evidence of retention of the wild type allele in tumours

We have recently shown that the CHEK2*1100delC mutation acts as a low penetrance breast cancer susceptibility allele. To investigate if other CHEK2 variants confer an increased risk of breast cancer, we have screened an affected individual with breast cancer from 68 breast cancer families. Five of t...

Descripción completa

Detalles Bibliográficos
Autores principales: Sodha, N, Bullock, S, Taylor, R, Mitchell, G, Guertl-Lackner, B, Williams, R D, Bevan, S, Bishop, K, McGuire, S, Houlston, R S, Eeles, R A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376278/
https://www.ncbi.nlm.nih.gov/pubmed/12454775
http://dx.doi.org/10.1038/sj.bjc.6600637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376278/
https://www.ncbi.nlm.nih.gov/pubmed/12454775
http://dx.doi.org/10.1038/sj.bjc.6600637

Ejemplares similares