Do altering in ornithine decarboxylase activity and gene expression contribute to antiproliferative properties of COX inhibitors?

Two isoforms of cyclooxygenase (COX) participate in growth control; COX-1 is constitutively expressed in most cells, and COX-2 is an inducible enzyme in response to cellular stimuli. An induction of COX-2 found in neoplastic tissues results in increased cell growth, inhibition of apoptosis, activati...

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Detalles Bibliográficos
Autores principales: Ostrowski, J, Wocial, T, Skurzak, H, Bartnik, W
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376368/
https://www.ncbi.nlm.nih.gov/pubmed/12671717
http://dx.doi.org/10.1038/sj.bjc.6600815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376368/
https://www.ncbi.nlm.nih.gov/pubmed/12671717
http://dx.doi.org/10.1038/sj.bjc.6600815

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