NF-κB inhibition impairs the radioresponse of hypoxic EMT-6 tumour cells through downregulation of inducible nitric oxide synthase

Hypoxic EMT-6 tumour cells displayed a high level of inducible nitric oxide synthase (iNOS) and an increased radiosensitivity after a 16 h exposure to lipopolysaccharide, a known activator of nuclear factor-κB (NF-κB). Both iNOS activation and radioresponse were impaired by the NF-κB inhibitors phen...

Descripción completa

Detalles Bibliográficos
Autores principales: Ridder, M De, Van den Berge, D L, Verovski, V N, Monsaert, C, Wauters, N, Storme, G A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376775/
https://www.ncbi.nlm.nih.gov/pubmed/12556970
http://dx.doi.org/10.1038/sj.bjc.6600678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376775/
https://www.ncbi.nlm.nih.gov/pubmed/12556970
http://dx.doi.org/10.1038/sj.bjc.6600678

Ejemplares similares