NF-κB inhibition impairs the radioresponse of hypoxic EMT-6 tumour cells through downregulation of inducible nitric oxide synthase

Hypoxic EMT-6 tumour cells displayed a high level of inducible nitric oxide synthase (iNOS) and an increased radiosensitivity after a 16 h exposure to lipopolysaccharide, a known activator of nuclear factor-κB (NF-κB). Both iNOS activation and radioresponse were impaired by the NF-κB inhibitors phen...

Descripción completa

Detalles Bibliográficos
Autores principales: Ridder, M De, Van den Berge, D L, Verovski, V N, Monsaert, C, Wauters, N, Storme, G A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376775/
https://www.ncbi.nlm.nih.gov/pubmed/12556970
http://dx.doi.org/10.1038/sj.bjc.6600678
_version_ 1782154736681615360
author Ridder, M De
Van den Berge, D L
Verovski, V N
Monsaert, C
Wauters, N
Storme, G A
author_facet Ridder, M De
Van den Berge, D L
Verovski, V N
Monsaert, C
Wauters, N
Storme, G A
author_sort Ridder, M De
collection PubMed
description Hypoxic EMT-6 tumour cells displayed a high level of inducible nitric oxide synthase (iNOS) and an increased radiosensitivity after a 16 h exposure to lipopolysaccharide, a known activator of nuclear factor-κB (NF-κB). Both iNOS activation and radioresponse were impaired by the NF-κB inhibitors phenylarsine oxide and lactacystin. Contrasting to other studies, our data show that inhibition of NF-κB may impair the radioresponse of tumour cells through downregulation of iNOS.
format Text
id pubmed-2376775
institution National Center for Biotechnology Information
language English
publishDate 2003
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-23767752009-09-10 NF-κB inhibition impairs the radioresponse of hypoxic EMT-6 tumour cells through downregulation of inducible nitric oxide synthase Ridder, M De Van den Berge, D L Verovski, V N Monsaert, C Wauters, N Storme, G A Br J Cancer Experimental Therapeutics Hypoxic EMT-6 tumour cells displayed a high level of inducible nitric oxide synthase (iNOS) and an increased radiosensitivity after a 16 h exposure to lipopolysaccharide, a known activator of nuclear factor-κB (NF-κB). Both iNOS activation and radioresponse were impaired by the NF-κB inhibitors phenylarsine oxide and lactacystin. Contrasting to other studies, our data show that inhibition of NF-κB may impair the radioresponse of tumour cells through downregulation of iNOS. Nature Publishing Group 2003-01-13 2003-01-28 /pmc/articles/PMC2376775/ /pubmed/12556970 http://dx.doi.org/10.1038/sj.bjc.6600678 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Experimental Therapeutics
Ridder, M De
Van den Berge, D L
Verovski, V N
Monsaert, C
Wauters, N
Storme, G A
NF-κB inhibition impairs the radioresponse of hypoxic EMT-6 tumour cells through downregulation of inducible nitric oxide synthase
title NF-κB inhibition impairs the radioresponse of hypoxic EMT-6 tumour cells through downregulation of inducible nitric oxide synthase
title_full NF-κB inhibition impairs the radioresponse of hypoxic EMT-6 tumour cells through downregulation of inducible nitric oxide synthase
title_fullStr NF-κB inhibition impairs the radioresponse of hypoxic EMT-6 tumour cells through downregulation of inducible nitric oxide synthase
title_full_unstemmed NF-κB inhibition impairs the radioresponse of hypoxic EMT-6 tumour cells through downregulation of inducible nitric oxide synthase
title_short NF-κB inhibition impairs the radioresponse of hypoxic EMT-6 tumour cells through downregulation of inducible nitric oxide synthase
title_sort nf-κb inhibition impairs the radioresponse of hypoxic emt-6 tumour cells through downregulation of inducible nitric oxide synthase
topic Experimental Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376775/
https://www.ncbi.nlm.nih.gov/pubmed/12556970
http://dx.doi.org/10.1038/sj.bjc.6600678
work_keys_str_mv AT riddermde nfkbinhibitionimpairstheradioresponseofhypoxicemt6tumourcellsthroughdownregulationofinduciblenitricoxidesynthase
AT vandenbergedl nfkbinhibitionimpairstheradioresponseofhypoxicemt6tumourcellsthroughdownregulationofinduciblenitricoxidesynthase
AT verovskivn nfkbinhibitionimpairstheradioresponseofhypoxicemt6tumourcellsthroughdownregulationofinduciblenitricoxidesynthase
AT monsaertc nfkbinhibitionimpairstheradioresponseofhypoxicemt6tumourcellsthroughdownregulationofinduciblenitricoxidesynthase
AT wautersn nfkbinhibitionimpairstheradioresponseofhypoxicemt6tumourcellsthroughdownregulationofinduciblenitricoxidesynthase
AT stormega nfkbinhibitionimpairstheradioresponseofhypoxicemt6tumourcellsthroughdownregulationofinduciblenitricoxidesynthase

Ejemplares similares