Cargando…

Correlation between 5-fluorouracil metabolism and treatment response in two variants of C26 murine colon carcinoma

Following an i.p. dose of 150 mg kg(−1) 5-fluorouracil (5-FU), drug uptake and metabolism over a 2-h period were studied by in vivo (19)F magnetic resonance spectroscopy (MRS) for the murine colon carcinoma lines C26-B (5-FU-insensitive; n=11) and C26-10 (5-FU-sensitive; n=15) implanted s.c. in Balb...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kamm, Y J L, Peters, G J, Hull, W E, Punt, C J A, Heerschap, A
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2003
Materias:	Experimental Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376920/ https://www.ncbi.nlm.nih.gov/pubmed/12915890 http://dx.doi.org/10.1038/sj.bjc.6601162

Ejemplares similares

Molecular mechanisms underlying the interaction between ZD1839 (‘Iressa’) and cisplatin/5-fluorouracil
por: Magné, N, et al.
Publicado: (2003)

Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivity
por: Etienne, M-C, et al.
Publicado: (2004)

Impact of the oxaliplatin-5 fluorouracil-folinic acid combination on respective intracellular determinants of drug activity
por: Fischel, J L, et al.
Publicado: (2002)

Regional localisation of p53-independent apoptosis determines toxicity to 5-fluorouracil and pyrrolidinedithiocarbamate in the murine gut
por: Bach, S P, et al.
Publicado: (2006)

Mechanism of cell death induced by the novel enzyme-prodrug combination, nitroreductase/CB1954, and identification of synergism with 5-fluorouracil
por: Palmer, D H, et al.
Publicado: (2003)

Non-invasive (19)F MR spectroscopy of 5-fluorocytosine to 5-fluorouracil conversion by recombinant Salmonella in tumours
por: Dresselaers, T, et al.
Publicado: (2003)

Antitumour activity of XR5944 in vitro and in vivo in combination with 5-fluorouracil and irinotecan in colon cancer cell lines
por: Harris, S M, et al.
Publicado: (2005)

Potential role of endocrine gastrin in the colonic adenoma carcinoma sequence
por: Watson, S A, et al.
Publicado: (2002)

c-Myc overexpression sensitises colon cancer cells to camptothecin-induced apoptosis
por: Arango, D, et al.
Publicado: (2003)

In vitro evaluation of cancer-specific NF-κB-CEA enhancer–promoter system for 5-fluorouracil prodrug gene therapy in colon cancer cell lines
por: Guo, X, et al.
Publicado: (2007)

Improved antitumour immunity in murine neuroblastoma using a combination of IL-2 and IL-12
por: Siapati, K E, et al.
Publicado: (2003)

APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis
por: Gebremariam, Teclegiorgis, et al.
Publicado: (2019)

Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model
por: Brown, N J, et al.
Publicado: (2002)

Signal transduction pathways involved in proteolysis-inducing factor induced proteasome expression in murine myotubes
por: Smith, H J, et al.
Publicado: (2003)

Modulation of colony stimulating factor release and apoptosis in human colon cancer cells by anticancer drugs
por: Calatayud, S, et al.
Publicado: (2002)

Dietary induction of NQO1 increases the antitumour activity of mitomycin C in human colon tumours in vivo
por: Begleiter, A, et al.
Publicado: (2004)

Effects of tumour acidification with glucose+MIBG on the spontaneous metastatic potential of two murine cell lines
por: Kalliomäki, T, et al.
Publicado: (2004)

Increased expression of the ubiquitin – proteasome pathway in murine myotubes by proteolysis-inducing factor (PIF) is associated with activation of the transcription factor NF-κB
por: Whitehouse, A S, et al.
Publicado: (2003)

Anti-angiogenic effects of the thienopyridine SR 25989 in vitro and in vivo in a murine pulmonary metastasis model
por: Mah-Becherel, M C M, et al.
Publicado: (2002)

N-(4-iodophenyl)-N′-(2-chloroethyl)urea as a microtubule disrupter: in vitro and in vivo profiling of antitumoral activity on CT-26 murine colon carcinoma cell line cultured and grafted to mice
por: Borel, M, et al.
Publicado: (2007)

δ-Aminolevulinic acid transport in murine mammary adenocarcinoma cells is mediated by beta transporters
por: Bermúdez Moretti, M, et al.
Publicado: (2002)

Murine 5T multiple myeloma cells induce angiogenesis in vitro and in vivo
por: Van Valckenborgh, E, et al.
Publicado: (2002)

Fas ligand mediates immune privilege and not inflammation in human colon cancer, irrespective of TGF-β expression
por: Houston, A, et al.
Publicado: (2003)

Effect of nonsteroidal anti-inflammatory drugs on β-catenin protein levels and catenin-related transcription in human colorectal cancer cells
por: Gardner, S H, et al.
Publicado: (2004)

Angiopoietin-1 inhibits tumour growth and ascites formation in a murine model of peritoneal carcinomatosis
por: Stoeltzing, O, et al.
Publicado: (2002)

In vivo bioluminescence imaging of locally disseminated colon carcinoma in rats
por: Zeamari, S, et al.
Publicado: (2004)

Efficacy of Delayed Therapy with Fosmanogepix (APX001) in a Murine Model of Candida auris Invasive Candidiasis
por: Wiederhold, Nathan P., et al.
Publicado: (2019)

Topical application of ALA and ALA hexyl ester on a subcutaneous murine mammary adenocarcinoma: tissue distribution
por: Perotti, C, et al.
Publicado: (2003)

Bactericidal and Sterilizing Activity of a Novel Regimen with Bedaquiline, Pretomanid, Moxifloxacin, and Pyrazinamide in a Murine Model of Tuberculosis
por: Li, Si-Yang, et al.
Publicado: (2017)

Contribution of Pretomanid to Novel Regimens Containing Bedaquiline with either Linezolid or Moxifloxacin and Pyrazinamide in Murine Models of Tuberculosis
por: Xu, Jian, et al.
Publicado: (2019)

Oestradiol enhances tumour regression induced by B7-1/IL-2 adenoviral gene transfer in a murine model of breast cancer
por: Dabrosin, C, et al.
Publicado: (2003)

Integrin αvβ6-associated ERK2 mediates MMP-9 secretion in colon cancer cells
por: Gu, X, et al.
Publicado: (2002)

Evaluation of Gallium Citrate Formulations against a Multidrug-Resistant Strain of Klebsiella pneumoniae in a Murine Wound Model of Infection
por: Thompson, Mitchell G., et al.
Publicado: (2015)

Radiosensitivity of human tumour cells is correlated with the induction but not with the repair of DNA double-strand breaks
por: El-Awady, R A, et al.
Publicado: (2003)

TNF autovaccination induces self anti-TNF antibodies and inhibits metastasis in a murine melanoma model
por: Waterston, A M, et al.
Publicado: (2004)

Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development
por: McCarthy, James S., et al.
Publicado: (2016)

Correlation between genetic alterations and growth of human malignant glioma xenografted in nude mice
por: Leuraud, P, et al.
Publicado: (2003)

Malignant germ cell tumours of the testis express interferon-γ, but are resistant to endogenous interferon-γ
por: Schweyer, S, et al.
Publicado: (2003)

Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco2)
por: Salucci, M, et al.
Publicado: (2002)

Molecular targeting of retinoic acid metabolism in neuroblastoma: the role of the CYP26 inhibitor R116010 in vitro and in vivo
por: Armstrong, J L, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_85tpf0l3791ao5gqtc5fgq40t7