High frequency of mitochondrial genome instability in human endometrial carcinomas

To investigate the occurrence of somatic mitochondrial DNA (mtDNA) mutations in human primary endometrial carcinomas, we sequenced the D-loop region, the 12S and 16S rRNA genes of mtDNA of cancer tissues and their matched normal controls. About 56% (28 out of 50) of cases carry one or more somatic c...

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Detalles Bibliográficos
Autores principales: Liu, V W S, Yang, H J, Wang, Y, Tsang, P C K, Cheung, A N Y, Chiu, P M, Ng, T Y, Wong, L C, Nagley, P, Ngan, H Y S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376924/
https://www.ncbi.nlm.nih.gov/pubmed/12915881
http://dx.doi.org/10.1038/sj.bjc.6601110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376924/
https://www.ncbi.nlm.nih.gov/pubmed/12915881
http://dx.doi.org/10.1038/sj.bjc.6601110

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