Her-2/neu-triggered intracellular tyrosine kinase activation: in vivo relevance of ligand-independent activation mechanisms and impact upon the efficacy of trastuzumab-based treatment

Proteolytic cleavage of the Her-2/neu extracellular domain (ECD) has been shown to initiate receptor phosphorylation representing Her-2/neu activation in vitro. The present investigation was performed to evaluate the clinical relevance of ECD cleavage for Her-2/neu activation and the consequences of...

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Detalles Bibliográficos
Autores principales: Hudelist, G, Köstler, W J, Attems, J, Czerwenka, K, Müller, R, Manavi, M, Steger, G G, Kubista, E, Zielinski, C C, Singer, C F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376939/
https://www.ncbi.nlm.nih.gov/pubmed/12966413
http://dx.doi.org/10.1038/sj.bjc.6601160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376939/
https://www.ncbi.nlm.nih.gov/pubmed/12966413
http://dx.doi.org/10.1038/sj.bjc.6601160

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