Cargando…

Functional screening of genes suppressing TRAIL-induced apoptosis: distinct inhibitory activities of Bcl-X(L) and Bcl-2

TNF-related apoptosis-inducing ligand (TRAIL) is known to selectively induce apoptosis in various tumour cells. However, downstream-signalling of TRAIL-receptor is not well defined. A functional genetic screening was performed to isolate genes interfering with TRAIL-induced apoptosis using cDNA retr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, I-K, Jung, Y-K, Noh, D-Y, Song, Y-S, Choi, C-H, Oh, B-H, Masuda, E S
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2003
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377084/ https://www.ncbi.nlm.nih.gov/pubmed/12644829 http://dx.doi.org/10.1038/sj.bjc.6600795

Ejemplares similares

A mechanism of resistance to TRAIL/Apo2L-induced apoptosis of newly established glioma cell line and sensitisation to TRAIL by genotoxic agents
por: Arizono, Y, et al.
Publicado: (2003)

Modulation of the Apoptosis Gene Bcl-x Function Through Alternative Splicing
por: Stevens, Megan, et al.
Publicado: (2019)

TRAIL-β and TRAIL-γ: two novel splice variants of the human TNF-related apoptosis-inducing ligand (TRAIL) without apoptotic potential
por: Krieg, A, et al.
Publicado: (2003)

The prognostic significance of apoptosis-associated proteins BCL-2, BAX and BCL-X in clinical nephroblastoma
por: Ghanem, M A, et al.
Publicado: (2001)

Acidic pre-conditioning suppresses apoptosis and increases expression of Bcl-xL in coronary endothelial cells under simulated ischaemia
por: Kumar, S, et al.
Publicado: (2008)

Prognostic significance of Bcl-xL expression and efficacy of Bcl-xL targeting therapy in urothelial carcinoma
por: Yoshimine, S, et al.
Publicado: (2013)

Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism
por: Lincoln, Frank A., et al.
Publicado: (2018)

Distinct association between aberrant methylation of Wnt inhibitors and genetic alterations in acute myeloid leukaemia
por: Hou, H-A, et al.
Publicado: (2011)

Apoptosis is augmented in high-grade serous ovarian cancer by the combined inhibition of Bcl-2/Bcl-xL and PARP
por: Yokoyama, Takuhei, et al.
Publicado: (2017)

Bcl-2 and Bcl-x(L) Suppress Glucose Signaling in Pancreatic β-Cells
por: Luciani, Dan S., et al.
Publicado: (2013)

High tumour islet macrophage infiltration correlates with improved patient survival but not with EGFR mutations, gene copy number or protein expression in resected non-small cell lung cancer
por: Kim, D-W, et al.
Publicado: (2008)

Radiosensitization by a novel Bcl-2 and Bcl-X(L) inhibitor S44563 in small-cell lung cancer
por: Loriot, Y, et al.
Publicado: (2014)

Overexpression of Betaig-h3 gene downregulates integrin α5β1 and suppresses tumorigenicity in radiation-induced tumorigenic human bronchial epithelial cells
por: Zhao, Y L, et al.
Publicado: (2002)

Regulation of apoptosis by an intrinsically disordered region of Bcl-xL
por: Follis, Ariele Viacava, et al.
Publicado: (2018)

CHOP mediates ASPP2-induced autophagic apoptosis in hepatoma cells by releasing Beclin-1 from Bcl-2 and inducing nuclear translocation of Bcl-2
por: Liu, K, et al.
Publicado: (2014)

Mitochondrial inhibitor sensitizes non-small-cell lung carcinoma cells to TRAIL-induced apoptosis by reactive oxygen species and Bcl-X(L)/p53-mediated amplification mechanisms
por: Shi, Y-L, et al.
Publicado: (2014)

Multifunctional transcription factor TFII-I is an activator of BRCA1 function
por: Tanikawa, M, et al.
Publicado: (2011)

Pro-Apoptotic Apoptosis Protease–Activating Factor 1 (Apaf-1) Has a Cytoplasmic Localization Distinct from Bcl-2 or Bcl-X(L)
por: Hausmann, George, et al.
Publicado: (2000)

Distinct Roles of Bcl-2 and Bcl-Xl in the Apoptosis of Human Bone Marrow Mesenchymal Stem Cells during Differentiation
por: Oliver, Lisa, et al.
Publicado: (2011)

Gene expression profiles in human gastric cancer: expression of maspin correlates with lymph node metastasis
por: Terashima, M, et al.
Publicado: (2005)

Regulation of alternative splicing of Bcl-x by BC200 contributes to breast cancer pathogenesis
por: Singh, R, et al.
Publicado: (2016)

Identification of DBC1 as a transcriptional repressor for BRCA1
por: Hiraike, H, et al.
Publicado: (2010)

Hyperstable U1snRNA complementary to the K-ras transcripts induces cell death in pancreatic cancer cells
por: Kato, K, et al.
Publicado: (2002)

WTH3 is a direct target of the p53 protein
por: Tian, K, et al.
Publicado: (2007)

Analysis of gene alterations of mitochondrial DNA D-loop regions to determine breast cancer clonality
por: Masuda, S, et al.
Publicado: (2012)

Genetic and epigenetic alterations on the short arm of chromosome 11 are involved in a majority of sporadic Wilms' tumours
por: Satoh, Y, et al.
Publicado: (2006)

Fibulin 1 is downregulated through promoter hypermethylation in gastric cancer
por: Cheng, Y Y, et al.
Publicado: (2008)

Distinct roles of mitochondria- and ER-localized Bcl-x(L) in apoptosis resistance and Ca(2+) homeostasis
por: Eno, Colins O., et al.
Publicado: (2012)

Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-xL
por: Reeve, Janice LV, et al.
Publicado: (2007)

miR-320c regulates gemcitabine-resistance in pancreatic cancer via SMARCC1
por: Iwagami, Y, et al.
Publicado: (2013)

MicroRNA deregulation and pathway alterations in nasopharyngeal carcinoma
por: Chen, H-C, et al.
Publicado: (2009)

Common genetic variability in ESR1 and EGF in relation to endometrial cancer risk and survival
por: Einarsdóttir, K, et al.
Publicado: (2009)

Bcl-xL inhibition by molecular-targeting drugs sensitizes human pancreatic cancer cells to TRAIL
por: Hari, Yoko, et al.
Publicado: (2015)

An antiapoptotic Bcl-2 family protein index predicts the response of leukaemic cells to the pan-Bcl-2 inhibitor S1
por: Zhang, Z, et al.
Publicado: (2013)

Met/HGF receptor modulates bcl-w expression and inhibits apoptosis in human colorectal cancers
por: Kitamura, S, et al.
Publicado: (2000)

High frequency of mitochondrial genome instability in human endometrial carcinomas
por: Liu, V W S, et al.
Publicado: (2003)

Differential gene expression profiles of gastric cancer cells established from primary tumour and malignant ascites
por: Sakakura, C, et al.
Publicado: (2002)

TNFα Cooperates with IFN-γ to Repress Bcl-xL Expression to Sensitize Metastatic Colon Carcinoma Cells to TRAIL-mediated Apoptosis
por: Liu, Feiyan, et al.
Publicado: (2011)

Alteration of the copy number and deletion of mitochondrial DNA in human hepatocellular carcinoma
por: Yin, P H, et al.
Publicado: (2004)

Reduced Fhit expression is associated with mismatch repair deficiency in human advanced colorectal carcinoma
por: Andachi, H, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_mf0penpti1guj95749jv2r430a