Cargando…

Absence of cyclin D2 expression is associated with promoter hypermethylation in gastric cancer

Expression of cyclin D2 is absent in 30–70% of gastric cancers. We investigated the role of promoter hypermethylation in the transcriptional silencing of cyclin D2 in five gastric cell lines and 47 primary gastric carcinomas. CpG island methylation status of the cyclin D2 gene was studied by methyla...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, J, Leung, W K, Ebert, M P A, Leong, R W L, Tse, P C H, Chan, M W Y, Bai, A H C, To, K F, Malfertheiner, P, Sung, J J Y
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377112/
https://www.ncbi.nlm.nih.gov/pubmed/12771922
http://dx.doi.org/10.1038/sj.bjc.6600940