Drug resistance associated with loss of p53 involves extensive alterations in microtubule composition and dynamics

In the present study, we compared the dynamics and composition of microtubules in cell lines derived from the human breast adenocarcinoma MCF-7 containing either the wild-type p53 (wt-p53; MN1) or a dominant-negative variant of p53 gene (mut-p53; MDD2). Mut-p53 cells were significantly resistant to...

Descripción completa

Detalles Bibliográficos
Autores principales: Galmarini, C M, Kamath, K, Vanier-Viornery, A, Hervieu, V, Peiller, E, Falette, N, Puisieux, A, Ann Jordan, M, Dumontet, C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377136/
https://www.ncbi.nlm.nih.gov/pubmed/12771997
http://dx.doi.org/10.1038/sj.bjc.6600960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377136/
https://www.ncbi.nlm.nih.gov/pubmed/12771997
http://dx.doi.org/10.1038/sj.bjc.6600960

Ejemplares similares