CpG methylation of MGMT and hMLH1 promoter in hepatocellular carcinoma associated with hepatitis viral infection

Inactivations of DNA repair genes, O(6)-methylguanine-DNA methyltransferase (MGMT) and hMLH1, by promoter hypermethylation have been reported in several types of primary human neoplasia. This epigenetic inactivation mechanism remains elusive in hepatocellular carcinoma (HCC). To investigate the rela...

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Detalles Bibliográficos
Autores principales: Matsukura, S, Soejima, H, Nakagawachi, T, Yakushiji, H, Ogawa, A, Fukuhara, M, Miyazaki, K, Nakabeppu, Y, Sekiguchi, M, Mukai, T
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377174/
https://www.ncbi.nlm.nih.gov/pubmed/12592365
http://dx.doi.org/10.1038/sj.bjc.6600743

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377174/
https://www.ncbi.nlm.nih.gov/pubmed/12592365
http://dx.doi.org/10.1038/sj.bjc.6600743

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