Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts

BACKGROUND: The polyglutamine expansion in huntingtin (Htt) protein is a cause of Huntington's disease (HD). Htt is an essential gene as deletion of the mouse Htt gene homolog (Hdh) is embryonic lethal in mice. Therefore, in addition to elucidating the mechanisms responsible for polyQ-mediated...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Hua, Das, Sudipto, Li, Quan-Zhen, Dragatsis, Ioannis, Repa, Joyce, Zeitlin, Scott, Hajnóczky, György, Bezprozvanny, Ilya
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377268/
https://www.ncbi.nlm.nih.gov/pubmed/18412970
http://dx.doi.org/10.1186/1471-2202-9-38

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377268/
https://www.ncbi.nlm.nih.gov/pubmed/18412970
http://dx.doi.org/10.1186/1471-2202-9-38

Ejemplares similares