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Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase/Visfatin Enzymatic Activity Identifies a New Inflammatory Pathway Linked to NAD
Nicotinamide phosphoribosyltransferase (NAMPT), also known as visfatin, is the rate-limiting enzyme in the salvage pathway of NAD biosynthesis from nicotinamide. Since its expression is upregulated during inflammation, NAMPT represents a novel clinical biomarker in acute lung injury, rheumatoid arth...
Autores principales: | Busso, Nathalie, Karababa, Mahir, Nobile, Massimo, Rolaz, Aline, Van Gool, Frédéric, Galli, Mara, Leo, Oberdan, So, Alexander, De Smedt, Thibaut |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377336/ https://www.ncbi.nlm.nih.gov/pubmed/18493620 http://dx.doi.org/10.1371/journal.pone.0002267 |
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