Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis

We describe the synthesis and characterization of a 5′ conjugate between a 2′-O-Me phosphorothioate antisense oligonucleotide and a bivalent RGD (arginine–glycine–aspartic acid) peptide that is a high-affinity ligand for the αvβ3 integrin. We used αvβ3-positive melanoma cells transfected with a repo...

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Detalles Bibliográficos
Autores principales: Alam, Md Rowshon, Dixit, Vidula, Kang, Hyunmin, Li, Zi-Bo, Chen, Xiaoyuan, Trejo, JoAnn, Fisher, Michael, Juliano, Rudy L.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377441/
https://www.ncbi.nlm.nih.gov/pubmed/18367474
http://dx.doi.org/10.1093/nar/gkn115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377441/
https://www.ncbi.nlm.nih.gov/pubmed/18367474
http://dx.doi.org/10.1093/nar/gkn115

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