Myofiber integrity depends on desmin network targeting to Z-disks and costameres via distinct plectin isoforms

Dysfunction of plectin, a 500-kD cytolinker protein, leads to skin blistering and muscular dystrophy. Using conditional gene targeting in mice, we show that plectin deficiency results in progressive degenerative alterations in striated muscle, including aggregation and partial loss of intermediate f...

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Detalles Bibliográficos
Autores principales: Konieczny, Patryk, Fuchs, Peter, Reipert, Siegfried, Kunz, Wolfram S., Zeöld, Anikó, Fischer, Irmgard, Paulin, Denise, Schröder, Rolf, Wiche, Gerhard
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386106/
https://www.ncbi.nlm.nih.gov/pubmed/18490514
http://dx.doi.org/10.1083/jcb.200711058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386106/
https://www.ncbi.nlm.nih.gov/pubmed/18490514
http://dx.doi.org/10.1083/jcb.200711058

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