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Myofiber integrity depends on desmin network targeting to Z-disks and costameres via distinct plectin isoforms
Dysfunction of plectin, a 500-kD cytolinker protein, leads to skin blistering and muscular dystrophy. Using conditional gene targeting in mice, we show that plectin deficiency results in progressive degenerative alterations in striated muscle, including aggregation and partial loss of intermediate f...
| Autores principales: | , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386106/ https://www.ncbi.nlm.nih.gov/pubmed/18490514 http://dx.doi.org/10.1083/jcb.200711058 |