Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes

Understanding the mechanisms of multidrug resistance (MDR) could improve clinical drug efficacy. Multidrug resistance is associated with ATP binding cassette (ABC) transporters, but the factors that regulate their expression at clinically relevant drug concentrations are poorly understood. We report...

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Detalles Bibliográficos
Autores principales: Calcagno, A M, Fostel, J M, To, K K W, Salcido, C D, Martin, S E, Chewning, K J, Wu, C-P, Varticovski, L, Bates, S E, Caplen, N J, Ambudkar, S V
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386965/
https://www.ncbi.nlm.nih.gov/pubmed/18382425
http://dx.doi.org/10.1038/sj.bjc.6604334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386965/
https://www.ncbi.nlm.nih.gov/pubmed/18382425
http://dx.doi.org/10.1038/sj.bjc.6604334

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