Quantitative Effect of Suboptimal Codon Usage on Translational Efficiency of mRNA Encoding HIV-1 gag in Intact T Cells

BACKGROUND: The sequences of wild-isolate strains of Human Immunodeficiency Virus-1 (HIV-1) are characterized by low GC content and suboptimal codon usage. Codon optimization of DNA vectors can enhance protein expression both by enhancing translational efficiency, and by altering RNA stability and e...

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Detalles Bibliográficos
Autores principales: Ngumbela, Kholiswa C., Ryan, Kieran P., Sivamurthy, Rohini, Brockman, Mark A., Gandhi, Rajesh T., Bhardwaj, Nina, Kavanagh, Daniel G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2387063/
https://www.ncbi.nlm.nih.gov/pubmed/18523584
http://dx.doi.org/10.1371/journal.pone.0002356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2387063/
https://www.ncbi.nlm.nih.gov/pubmed/18523584
http://dx.doi.org/10.1371/journal.pone.0002356

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