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Quantitative correlation between promoter methylation and messenger RNA levels of the reduced folate carrier
BACKGROUND: Methotrexate (MTX) uptake is mediated by the reduced folate carrier (RFC). Defective drug uptake in association with decreased RFC expression is a common mechanism of MTX resistance in many tumor types. Heavy promoter methylation was previously identified as a basis for the complete sile...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2387170/ https://www.ncbi.nlm.nih.gov/pubmed/18452618 http://dx.doi.org/10.1186/1471-2407-8-124 |