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Exploiting the pathway structure of metabolism to reveal high-order epistasis

BACKGROUND: Biological robustness results from redundant pathways that achieve an essential objective, e.g. the production of biomass. As a consequence, the biological roles of many genes can only be revealed through multiple knockouts that identify a set of genes as essential for a given function....

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Detalles Bibliográficos
Autores principales: Imielinski, Marcin, Belta, Calin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2390508/
https://www.ncbi.nlm.nih.gov/pubmed/18447928
http://dx.doi.org/10.1186/1752-0509-2-40