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Exploiting the pathway structure of metabolism to reveal high-order epistasis
BACKGROUND: Biological robustness results from redundant pathways that achieve an essential objective, e.g. the production of biomass. As a consequence, the biological roles of many genes can only be revealed through multiple knockouts that identify a set of genes as essential for a given function....
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2390508/ https://www.ncbi.nlm.nih.gov/pubmed/18447928 http://dx.doi.org/10.1186/1752-0509-2-40 |