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In vivo consequences of deleting EGF repeats 8–12 including the ligand binding domain of mouse Notch1
BACKGROUND: Notch signaling is highly conserved in the metazoa and is critical for many cell fate decisions. Notch activation occurs following ligand binding to Notch extracellular domain. In vitro binding assays have identified epidermal growth factor (EGF) repeats 11 and 12 as the ligand binding d...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2390518/ https://www.ncbi.nlm.nih.gov/pubmed/18445292 http://dx.doi.org/10.1186/1471-213X-8-48 |