A Drosophila Model of ALS: Human ALS-Associated Mutation in VAP33A Suggests a Dominant Negative Mechanism

ALS8 is caused by a dominant mutation in an evolutionarily conserved protein, VAPB (vesicle-associated membrane protein (VAMP)-associated membrane protein B)/ALS8). We have established a fly model of ALS8 using the corresponding mutation in Drosophila VAPB (dVAP33A) and examined the effects of this...

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Detalles Bibliográficos
Autores principales: Ratnaparkhi, Anuradha, Lawless, George M., Schweizer, Felix E., Golshani, Peyman, Jackson, George R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2390852/
https://www.ncbi.nlm.nih.gov/pubmed/18523548
http://dx.doi.org/10.1371/journal.pone.0002334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2390852/
https://www.ncbi.nlm.nih.gov/pubmed/18523548
http://dx.doi.org/10.1371/journal.pone.0002334

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