KCNQ1 and KCNE1 in the I(Ks) Channel Complex Make State-dependent Contacts in their Extracellular Domains

KCNQ1 and KCNE1 (Q1 and E1) associate to form the slow delayed rectifier I(Ks) channels in the heart. A short stretch of eight amino acids at the extracellular end of S1 in Q1 (positions 140–147) harbors six arrhythmia-associated mutations. Some of these mutations affect the Q1 channel function only...

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Detalles Bibliográficos
Autores principales: Xu, Xulin, Jiang, Min, Hsu, Kai-Ling, Zhang, Mei, Tseng, Gea-Ny
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2391252/
https://www.ncbi.nlm.nih.gov/pubmed/18504315
http://dx.doi.org/10.1085/jgp.200809976

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2391252/
https://www.ncbi.nlm.nih.gov/pubmed/18504315
http://dx.doi.org/10.1085/jgp.200809976

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