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Further observations on LKB1/STK11 status and cancer risk in Peutz–Jeghers syndrome
Germline mutations in the LKB1/STK11 tumour suppressor gene cause Peutz–Jeghers syndrome (PJS), a rare dominant disorder. In addition to typical hamartomatous gastrointestinal polyps and pigmented perioral lesions, PJS is associated with an increased risk of tumours at multiple sites. Follow-up info...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2003
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394252/ https://www.ncbi.nlm.nih.gov/pubmed/12865922 http://dx.doi.org/10.1038/sj.bjc.6601030 |