Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR–β1 integrin complex in colon cancer cells

Cancer invasion is regulated by cell surface proteinases and adhesion molecules. Interaction between specific cell surface molecules such as urokinase plasminogen activator receptor (uPAR) and integrins is crucial for tumour invasion and metastasis. In this study, we examined whether uPAR and β1 int...

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Detalles Bibliográficos
Autores principales: Ahmed, N, Oliva, K, Wang, Y, Quinn, M, Rice, G
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394266/
https://www.ncbi.nlm.nih.gov/pubmed/12865932
http://dx.doi.org/10.1038/sj.bjc.6601098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394266/
https://www.ncbi.nlm.nih.gov/pubmed/12865932
http://dx.doi.org/10.1038/sj.bjc.6601098

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