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P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivo
ABC transporter proteins may protect haematopoietic progenitor cells from chemotherapy-induced toxicity. By using an in vitro colony-forming assay, we found that bone marrow of Mdr1ab, Mrp1, Mdr1ab/Mrp1 knockout (KO) mice was two-, five- to 10- and 25-fold, respectively, more sensitive to vincristin...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2003
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394394/ https://www.ncbi.nlm.nih.gov/pubmed/14583783 http://dx.doi.org/10.1038/sj.bjc.6601363 |