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P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivo

ABC transporter proteins may protect haematopoietic progenitor cells from chemotherapy-induced toxicity. By using an in vitro colony-forming assay, we found that bone marrow of Mdr1ab, Mrp1, Mdr1ab/Mrp1 knockout (KO) mice was two-, five- to 10- and 25-fold, respectively, more sensitive to vincristin...

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Detalles Bibliográficos
Autores principales:	van Tellingen, O, Buckle, T, Jonker, J W, van der Valk, M A, Beijnen, J H
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2003
Materias:	Molecular and Cellular Pathology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394394/ https://www.ncbi.nlm.nih.gov/pubmed/14583783 http://dx.doi.org/10.1038/sj.bjc.6601363

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