Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity

Recent studies have shown that mutations at amino-acid 482 in the ABCG2 gene affect the substrate specificity of the protein. To delineate the effects of these mutations clearly, human embryonic kidney cells (HEK-293) were stably transfected with wild-type 482R or mutant 482G and 482T ABCG2. By flow...

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Detalles Bibliográficos
Autores principales: Robey, R W, Honjo, Y, Morisaki, K, Nadjem, T A, Runge, S, Risbood, M, Poruchynsky, M S, Bates, S E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394461/
https://www.ncbi.nlm.nih.gov/pubmed/14612912
http://dx.doi.org/10.1038/sj.bjc.6601370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394461/
https://www.ncbi.nlm.nih.gov/pubmed/14612912
http://dx.doi.org/10.1038/sj.bjc.6601370

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