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Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity

Recent studies have shown that mutations at amino-acid 482 in the ABCG2 gene affect the substrate specificity of the protein. To delineate the effects of these mutations clearly, human embryonic kidney cells (HEK-293) were stably transfected with wild-type 482R or mutant 482G and 482T ABCG2. By flow...

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Detalles Bibliográficos
Autores principales:	Robey, R W, Honjo, Y, Morisaki, K, Nadjem, T A, Runge, S, Risbood, M, Poruchynsky, M S, Bates, S E
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2003
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394461/ https://www.ncbi.nlm.nih.gov/pubmed/14612912 http://dx.doi.org/10.1038/sj.bjc.6601370

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