Inhibition of telomerase activity in malignant glioma cells correlates with their sensitivity to temozolomide

Temozolomide (TMZ, 3,4-dihydro-3-methyl-4-oxoimidazo [5,1-d]-as-tetrazine-8-carboxamide) is a new alkylating agent with promising antitumour efficacy for malignant gliomas. The resistance of tumour cells to TMZ is primarily associated with levels of the alkylguanine alkyltransferase (AGT). O(6)-benz...

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Detalles Bibliográficos
Autores principales: Kanzawa, T, Germano, I M, Kondo, Y, Ito, H, Kyo, S, Kondo, S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394478/
https://www.ncbi.nlm.nih.gov/pubmed/12942127
http://dx.doi.org/10.1038/sj.bjc.6601193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394478/
https://www.ncbi.nlm.nih.gov/pubmed/12942127
http://dx.doi.org/10.1038/sj.bjc.6601193

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