Functional analysis of the actin-binding protein, tropomyosin 1, in neuroblastoma

Tropomyosin 1 (TM1) is downregulated in a number of transformed cell types, and exogenous expression of TM1 can restore actin organisation and reverse cellular transformation. We find that TM1 is also downregulated in human neuroblastoma cell lines, correlating with increasing malignancy. However, e...

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Autores principales: Yager, M L, Hughes, J A I, Lovicu, F J, Gunning, P W, Weinberger, R P, O'Neill, G M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394486/
https://www.ncbi.nlm.nih.gov/pubmed/12942118
http://dx.doi.org/10.1038/sj.bjc.6601201
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author Yager, M L
Hughes, J A I
Lovicu, F J
Gunning, P W
Weinberger, R P
O'Neill, G M
author_facet Yager, M L
Hughes, J A I
Lovicu, F J
Gunning, P W
Weinberger, R P
O'Neill, G M
author_sort Yager, M L
collection PubMed
description Tropomyosin 1 (TM1) is downregulated in a number of transformed cell types, and exogenous expression of TM1 can restore actin organisation and reverse cellular transformation. We find that TM1 is also downregulated in human neuroblastoma cell lines, correlating with increasing malignancy. However, exogenous TM1 does not restore actin cytoskeleton organisation in neuroblastoma cells.
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spelling pubmed-23944862009-09-10 Functional analysis of the actin-binding protein, tropomyosin 1, in neuroblastoma Yager, M L Hughes, J A I Lovicu, F J Gunning, P W Weinberger, R P O'Neill, G M Br J Cancer Molecular and Cellular Pathology Tropomyosin 1 (TM1) is downregulated in a number of transformed cell types, and exogenous expression of TM1 can restore actin organisation and reverse cellular transformation. We find that TM1 is also downregulated in human neuroblastoma cell lines, correlating with increasing malignancy. However, exogenous TM1 does not restore actin cytoskeleton organisation in neuroblastoma cells. Nature Publishing Group 2003-09-01 2003-08-26 /pmc/articles/PMC2394486/ /pubmed/12942118 http://dx.doi.org/10.1038/sj.bjc.6601201 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular and Cellular Pathology
Yager, M L
Hughes, J A I
Lovicu, F J
Gunning, P W
Weinberger, R P
O'Neill, G M
Functional analysis of the actin-binding protein, tropomyosin 1, in neuroblastoma
title Functional analysis of the actin-binding protein, tropomyosin 1, in neuroblastoma
title_full Functional analysis of the actin-binding protein, tropomyosin 1, in neuroblastoma
title_fullStr Functional analysis of the actin-binding protein, tropomyosin 1, in neuroblastoma
title_full_unstemmed Functional analysis of the actin-binding protein, tropomyosin 1, in neuroblastoma
title_short Functional analysis of the actin-binding protein, tropomyosin 1, in neuroblastoma
title_sort functional analysis of the actin-binding protein, tropomyosin 1, in neuroblastoma
topic Molecular and Cellular Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394486/
https://www.ncbi.nlm.nih.gov/pubmed/12942118
http://dx.doi.org/10.1038/sj.bjc.6601201
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