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Fragment approaches in structure-based drug discovery
There has been considerable interest recently in what is known as ‘fragment-based lead discovery’. The novel feature of the approach is to begin with small low-affinity compounds. The main advantage is that a larger potential chemical diversity can be sampled with fewer compounds, which is particula...
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394783/ https://www.ncbi.nlm.nih.gov/pubmed/18421145 http://dx.doi.org/10.1107/S090904950705666X |