Structural insights into the similar modes of Nrf2 transcription factor recognition by the cytoplasmic repressor Keap1

The cytoplasmic repressor Keap1 regulates the function of transcription factor Nrf2 which plays critical roles in oxidative and xenobiotic stresses. The Neh2 domain of Nrf2 interacts with Keap1 at the bottom region of the Kelch/β-propeller domain which is formed by double-glycine repeat and C-termin...

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Detalles Bibliográficos
Autores principales: Padmanabhan, Balasundaram, Tong, Kit I., Kobayashi, Akira, Yamamoto, Masayuki, Yokoyama, Shigeyuki
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Diffraction Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394801/
https://www.ncbi.nlm.nih.gov/pubmed/18421157
http://dx.doi.org/10.1107/S090904950705114X

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394801/
https://www.ncbi.nlm.nih.gov/pubmed/18421157
http://dx.doi.org/10.1107/S090904950705114X

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