Highly selective toxic and proapoptotic effects of two dimeric ribonucleases on thyroid cancer cells compared to the effects of doxorubicin

The lack of selectivity of conventional antitumour drugs against cancer cells is responsible for their high toxicity. The development of new tumour-specific drugs is therefore highly needed. We tested the cytotoxic effects and the nature of cell death induced by a naturally dimeric bovine RNase and...

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Detalles Bibliográficos
Autores principales: Spalletti-Cernia, D, Sorrentino, R, Di Gaetano, S, Piccoli, R, Santoro, M, D'Alessio, G, Laccetti, P, Vecchio, G
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395318/
https://www.ncbi.nlm.nih.gov/pubmed/14710239
http://dx.doi.org/10.1038/sj.bjc.6601491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395318/
https://www.ncbi.nlm.nih.gov/pubmed/14710239
http://dx.doi.org/10.1038/sj.bjc.6601491

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