Sulindac targets nuclear β-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines

Nonsteroidal anti-inflammatory drugs (NSAIDs) have chemopreventive potential against colorectal carcinomas (CRCs). Inhibition of cyclooxygenase (COX)-2 underlies part of this effect, although COX-2-independent mechanisms may also exist. Nonsteroidal anti-inflammatory drugs appear to inhibit the init...

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Detalles Bibliográficos
Autores principales: Boon, E M J, Keller, J J, Wormhoudt, T A M, Giardiello, F M, Offerhaus, G J A, van der Neut, R, Pals, S T
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Experimental Therapeutic
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395323/
https://www.ncbi.nlm.nih.gov/pubmed/14710233
http://dx.doi.org/10.1038/sj.bjc.6601505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395323/
https://www.ncbi.nlm.nih.gov/pubmed/14710233
http://dx.doi.org/10.1038/sj.bjc.6601505

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