A Probabilistic Model of Local Sequence Alignment That Simplifies Statistical Significance Estimation

Sequence database searches require accurate estimation of the statistical significance of scores. Optimal local sequence alignment scores follow Gumbel distributions, but determining an important parameter of the distribution (λ) requires time-consuming computational simulation. Moreover, optimal al...

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Detalles Bibliográficos
Autor principal: Eddy, Sean R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396288/
https://www.ncbi.nlm.nih.gov/pubmed/18516236
http://dx.doi.org/10.1371/journal.pcbi.1000069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396288/
https://www.ncbi.nlm.nih.gov/pubmed/18516236
http://dx.doi.org/10.1371/journal.pcbi.1000069

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