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Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron

RNA interference (RNAi) is a powerful approach to inhibit human immunodeficiency virus type 1 (HIV-1) replication. However, HIV-1 can escape from RNAi-mediated antiviral therapy by selection of mutations in the targeted sequence. To prevent viral escape, multiple small interfering RNAs (siRNAs) agai...

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Detalles Bibliográficos
Autores principales:	Liu, Ying Poi, Haasnoot, Joost, ter Brake, Olivier, Berkhout, Ben, Konstantinova, Pavlina
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396423/ https://www.ncbi.nlm.nih.gov/pubmed/18346971 http://dx.doi.org/10.1093/nar/gkn109

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