Tolerance for 8-oxoguanine but not thymine glycol in alignment-based gap filling of partially complementary double-strand break ends by DNA polymerase λ in human nuclear extracts

Ionizing radiation induces various clustered DNA lesions, including double-strand breaks (DSBs) accompanied by nearby oxidative base damage. Previous work showed that, in HeLa nuclear extracts, DSBs with partially complementary 3′ overhangs and a one-base gap in each strand are accurately rejoined,...

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Detalles Bibliográficos
Autores principales: Zhou, Rui-Zhe, Blanco, Luis, Garcia-Diaz, Miguel, Bebenek, Katarzyna, Kunkel, Thomas A., Povirk, Lawrence F.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396438/
https://www.ncbi.nlm.nih.gov/pubmed/18385158
http://dx.doi.org/10.1093/nar/gkn126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396438/
https://www.ncbi.nlm.nih.gov/pubmed/18385158
http://dx.doi.org/10.1093/nar/gkn126

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