P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis

Nucleotides are released from cells in response to mechanical stimuli and signal in an autocrine/paracrine manner through cell surface P2 receptors. P2rx7(−/−) mice exhibit diminished appositional growth of long bones and impaired responses to mechanical loading. We find that calvarial sutures are w...

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Detalles Bibliográficos
Autores principales: Panupinthu, Nattapon, Rogers, Joseph T., Zhao, Lin, Solano-Flores, Luis Pastor, Possmayer, Fred, Sims, Stephen M., Dixon, S. Jeffrey
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396816/
https://www.ncbi.nlm.nih.gov/pubmed/18519738
http://dx.doi.org/10.1083/jcb.200708037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396816/
https://www.ncbi.nlm.nih.gov/pubmed/18519738
http://dx.doi.org/10.1083/jcb.200708037

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